IndraLab

Statements

Kv4.3 activates KCNH2. 5 / 5
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"In the presence of Kv4.3, more hERG protein localized on the surface of the cells, thus suggesting that Kv4.3 enhances hERG trafficking."
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"These results suggest that Kv4.3 enhances hERG protein trafficking through Hsp70."
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"Co-transfection of Kv4.3 increased I hERG densities, compared with cells transfected with hERG alone."
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"Co-expression of Kv4.3 with hERG increased hERG current density (tail current after a step to +10 mV : 26 +/-3 versus 56 +/-7 pA/pF, p < 0.01)."
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"Based on aforementioned studies, we hypothesize that Hsp70 may be involved in the maturation of hERG induced by Kv4.3."
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