IndraLab

Statements


Modified USP10 decreases the amount of ubiquitinated CFTR. 2 / 2
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"siRNA mediated reduction of USP10 protein expression (by 76 +/-4%, XREF_FIG) increased the amount of ubiquitinated CFTR."

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"Moreover, a dominant negative USP10 (USP10-C424A) increased the amount of ubiquitinated CFTR and its degradation, whereas overexpression of wt-USP10 decreased the amount of ubiquitinated CFTR and increased the abundance of CFTR."