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USP22 deubiquitinates MYC. 7 / 8
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"Skp2 is a ubiquitin ligase of Myc, which promotes the polyubiquitination and degradation of Myc during normal lymphocytes G1 to S phase transition [145], and USP22 mediates the deubiquitination of c-Myc to promote breast cancer progression [146]."
37190313
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"Similar results were obtained in the exogenous Co-IP assays that were carried out on HEK293T cells transfected with Flag-USP22 or/and HA-c-Myc ( Figures 5 C and D), which corroborated that c-Myc is a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, overexpression of USP22 upregulates the level of oncogenic c-MYC in breast cancer by promoting the deubiquitination of c-MYC, which is closely related with the progression of breast cance[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It could be through a direct mechanism where USP22 deubiquitylates c-MYC inducing its stabilization and activation, or indirectly through ubiquitin removal from histones at c-MYC target genes, recruitment of other transcriptional machinery or deubiquitylation of proteins important for c-MYC activity."
27057639
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"It has been established that USP22 is required for c-MYC transcriptional activity, through a direct mechanism where USP22 deubiquitylates c-MYC, causing its stabilization or activation, or indirectly through the recruitment of other transcriptional machinery, or by the removal of ubiquitin from histones at c-MYC target genes."
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"USP22 promotes the deubiquitination of c-MYC in breast cancer cells, resulting in an increase in c-MYC level (65)."
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"We found that USP22 promotes deubiquitination of c-Myc in several breast cancer cell lines, resulting in increased levels of c-Myc."
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