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PSMD14 activates Neoplasm Invasiveness. 42 / 42
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"PSMD14 overexpression enhances trophoblast migration and invasion in addition to promoting HUVEC angiogenesis."
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"In cancer progression, high levels of PSMD14 also enhanced the proliferation, migration and invasion cancer cells, such as breast cancer , ovarian cancer , bladder cancer , etc."
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"However, PSMD14 knockdown in KYSE30 cells greatly inhibited their ability of migration and invasion ( Fig. 4 B), indicating that PSMD14 could improve tumor cell motility in vitro ."
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"These results suggest that PSMD14 overexpression enhances trophoblast migration and invasion, in addition to HUVEC angiogenesis."
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"Knockdown and overexpression experiments elucidated that PSMD14 stimulated OV cell proliferation , invasion and migration in vitro ."
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"Gain- and loss-of-function experiments showed that silencing PSMD14 notably attenuated the growth, invasion, and metastasis of TNBC cells in vitro and in vivo."
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"PSMD14 knockdown inhibits in vitro cell proliferation, migration, invasion, and in vivo tumor growth."
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"Moreover, we established anlotinib-resistant osteosarcoma sublines and verified that PSMD14 was significantly expressed in the sublines and that PSMD14 knockdown could reduce the proliferation, migration, and invasion of resistant lines, as well as reverse anlotinib resistance."
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"PSMD14 promotes the proliferation, migration, and invasion of TNBC cells."
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"Knockdown and overexpression experiments elucidated that PSMD14 stimulated OV cell proliferation, invasion and migration in vitro."
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"PSMD14 knockdown substantially reduced the migration (Fig. 3A–C) and invasion of U2OS and Saos-2 cells (Fig. 3D–F), and we also discovered that wound healing was impaired in both osteosarcoma cell lines (Fig. 3G–I)."
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"For instance, PSMD14 is upregulated in esophageal squamous cell carcinoma (ESCC) tissues and can promote tumor cell migration and invasion through the PSMD14/SNAIL axis [47]."
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"PSMD14 overexpression was found to promote the proliferation, invasion, migration of HTR-8/SVneo cells and the angiogenesis of HUVECs following treatment with the HTR-8/SVneo cell culture supernatant, accompanied by enhanced expression of proliferation and migration-related proteins."
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"The results of biological function assays showed that PSMD14 silencing markedly decreased proliferation, migration, and invasiveness, but these effects were reversed in the TNBC cells co-transfected with sh-PSMD14 and FADS1-expressing plasmids (Fig. 6, A to D, and fig."
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"PSMD14 can promote phenotypic changes in HCC cells in vitro, including affecting cell proliferation invasion and migration."
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"We found that POH1 knockdown significantly reduced the migration and invasion capability of HCC cells (Fig. 6a)."
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"In contrast, overexpression of POH1 significantly accelerated TGF-β-induced migration and invasion of HCC cells tested by transwell and wound healing assays (Fig. S5a-b), without altering the growth rate in vitro (Fig. S5c)."
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"In conclusion, HEY1-activated PSMD14 promoted trophoblast proliferation, invasion and angiogenesis."
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"PSMD14 is highly expressed in esophageal cancer in esophageal cancer, and inhibition of PSMD14 inhibits tumor cell migration, invasion and EMT [29]."
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"PSMD14 knockdown plus anlotinib treatment significantly inhibited the proliferation, invasion, and migration of resistant sublines compared to anlotinib or PSMD14 knockdown treatment alone."
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"Therefore, although PSMD14 overexpression enhanced trophoblast migration, invasion and HUVEC angiogenesis, HEY1 knockdown was able to at least partially reverse these changes."
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"PSMD14 knockdown inhibited PC cell viability, proliferation, migration, and invasion."
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"Furthermore, we observed that PSMD14 promoted proliferation, migration, and invasion in vitro and tumor growth metastasis in vivo by stabilizing GRB2 protein."
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"Further in vivo and clinical studies are required to verify the findings in the present study.In conclusion, the present study demonstrated that HEY1 can activate PSMD14 expression, thereby promoting trophoblast proliferation, invasion and migration, in addition to downstream endothelial angiogenesis."
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"Functionally, PSMD14 promotes the proliferation and invasiveness of ATC cells, whereas the depletion of PSMD14 or PSMD14 inhibitor thiolutin (THL) inhibits the growth, invasiveness, and epithelial-mesenchymal transition ((EMT) of ATC cells."
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"In addition, PSMD14 can promote phenotypic changes in HCC cells in vitro, fostering cell proliferation invasion and migration."
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"Given that POH1 regulates the stability of Smad3, we propose that POH1 affects Smad3-mediated cellular function and promotes cell invasion and tumor metastasis in NCSLC."
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"Transwell assay demonstrated that knockdown of PSMD14 dramatically decreased the migration and invasion capacity of SMMC-7721, PLC/PRF/5, and MHCC-97h cells as compared with that of control groups ( F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Conversely, the cell migration and invasion ability was significantly enhanced by ectopic overexpression of PSMD14 in SMMC-7721 and PLC/PRF/5 cells ( Fig. 3 B)."
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"PSMD14 knockdown notably inhibited cell proliferation , migration , and invasion in vitro , which was confirmed through in vivo experiments ."
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"These findings suggested that POH1 promotes cell migration and invasion by stabilizing Smad3.POH1 promotes cell proliferation and tumor growth in breast cancer [ 26 ], hepatocellular carcinoma [ 26 , [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, our findings showed that PSMD14 promoted in vitro proliferation, migration, and invasion of HCC cells, and facilitated tumor growth and metastasis in vivo ."
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"The results of the transwell assays revealed that the ability of silencing PSMD14 to suppress migration and invasion was restored through the overexpression of CARM1 (Fig. 4C)."
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"Knockdown of PSMD14 in osteosarcoma cells reduced the viability, proliferation, and invasion activities of osteosarcoma cells in vitro."
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"Consistently, our findings demonstrate that POH1 promotes cell proliferation, invasion, and metastasis in NSCLS by mediating Smad3 stability."
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"Recently, a study found that the expression of PSMD14 is reduced in PE patients, and upregulation of PSMD14 expression promoted the proliferation and invasion of placental trophoblast cells ."
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"Knockdown of PSMD11 and PSMD14 significantly inhibited the proliferation, migration, and invasion ability of pancreatic cancer cells."
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"CARM1 was important for PSMD14-enhanced proliferation, migration, and invasion in HCC cells."
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"Knockdown of PSMD11 and PSMD14 reduces PDAC cell proliferation, invasion and migration."
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"In doing so, POH1 promotes migration and invasion via TGF-β signaling [175]."
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"In summary, PSMD11 and PSMD14 could promote the proliferation, invasion, and migration of PDAC cells."
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"As reported by Zhang et al. , PSMD14 enhanced the proliferation as well as invasion of trophoblast, which might be a potential targets for PE treatment."
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