IndraLab

Statements

Matrine increases the amount of KCNH2. 6 / 6
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"Matrine and oxymatrine could up-regulate the expression of the hERG channel to normal and also get the hERG step currents and tail currents to come back after long-term As 2 O 3 treatment."
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"In addition, matrine (1 μm) could also rescue the hERG current and hERG surface expression inhibited by probucol, thus providing a secure guarantee for the clinical use of probucol ( Shi et al., 2020 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we demonstrated that 1 muM matrine and oxymatrine could rescue the hERG current and hERG surface expression inhibited by probucol."
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"Interestingly, our previous studies showed that both matrine and oxymatrine increased hERG channel surface expression [20] and that oxymatrine activated the hERG channel [21] ."
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"Nonetheless, the mechanism of matrine and oxymatrine that increases hERG channel expression, and whether matrine and oxymatrine can modulate hERG channel expression reduced by As 2 O 3 remain unknown.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We proposed that matrine and oxymatrine might increase the expression of transcription factor Sp1, which is able to up-regulate hERG channel expression by activating the hERG promoter."
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