IndraLab

Statements

USP16 binds ISG15. 6 / 6
1 | 5
sparser
"When we compare the AF3 model of USP16 binding to ISG15 with our crystal structures of ISG15 bound to VHH ISG15-A or VHH ISG15-B , we would predict that only VHH ISG15-A would exhibit mutually exclusive binding because of a steric clash ( xref A )."
40774387
sparser
"It is therefore still unclear whether the ZnF domain of USP16 binds free ISG15 in the same mode as free Ub, and if it plays a regulatory role in ISG15-dependent processes in cells."
38055744
sparser
"Since our R153Agb mutant probes bind and interact with USP16 to some extent, our ongoing investigation also includes understanding the molecular interactions between ISG15 and USP16 that can help design more selective probes with increased affinity for USP18 and minimal or no cross-reactivity with USP16."
39843430
sparser
"Although a structure of the USP16–ISG15 complex remains to be determined, AF3 predicts that ISG15 interacts with USP16 at both N- and C-terminal domains ( xref A )."
40774387
sparser
"Compound 25 was shown to disrupt the wildtype HDAC6/ISG15 BRET signal in a dose-dependent manner to the same level as HDAC6 R1155A, Y1184A . To assess the selectivity of 25 in cells, a NanoBRET assay was designed to assess USP16-ISG15 interaction."
37499118
biogrid
No evidence text available
37499118