IndraLab

Statements

Propofol inhibits HCN1. 10 / 10
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"Nonetheless, these data argue strongly that ketamine and propofol inhibit HCN1 containing channels and dendritic I h in cortical neurons to mediate enhanced dendritosomatic synaptic integration."
19158287
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"Chen and colleagues argue that the case for HCN1 is stronger than the case for NMDA receptors, because the HCN1 knockout has no effect on etomidate sensitivity (but does decrease sensitivity to propofol, which inhibits HCN1), whereas global knockout of the NMDA receptor epsilon1 subunit moderately reduces ketamine sensitivity, but also reduces sensitivity to pentobarbital, propofol, and benzodiazepines, all thought to act primarily via GABA A receptors."
23364596
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"The alkylphenol general anesthetic propofol (2,6-di-iso-propylphenol) selectively inhibits HCN1 channels versus HCN2-HCN4 and exhibits a modest pharmacokinetic preference for the periphery."
23549867
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"Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core."
17569731
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"The alkylphenol general anesthetic propofol (2,6-di-iso-propylphenol) selectively inhibits HCN1 channels versus HCN2-HCN4 and exhibits a modest pharmacokinetic preference for the periphery."
23549867
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"Propofol inhibited and slowed the activation of recombinant HCN1, HCN2, and HCN4 channels at clinically relevant concentrations, in which the HCN1 current was the most sensitive of the three."
21642950
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"In addition, hypnotic sensitivity to two other intravenous anesthetics in HCN1 knockout mice matched effects on HCN1 channels; propofol selectively inhibited HCN1 channels and propofol sensitivity was diminished in HCN1 knockout mice whereas etomidate had no effect on HCN1 channels and hypnotic sensitivity to etomidate was unaffected by HCN1 gene deletion."
19158287
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"We found a good correlation between effects of two other anesthetic drugs on HCN1 subunits and their hypnotic actions in HCN1 knockout mice; etomidate had no effect on HCN1 channels and its ability to evoke a LORR was unaltered in HCN1 knockout mice whereas propofol selectively inhibits HCN1 subunits and we found a significant decrease in sensitivity of HCN1 knockout mice to hypnotic effects of propofol."
19158287
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"2,6-di-iso-propyl phenol (propofol) and its non-anesthetic congener, 2,6-di-tert-butyl phenol, inhibit HCN1 channels by stabilizing closed state(s)."
30768926
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"We found a good correlation between effects of two other anesthetic drugs on HCN1 subunits and their hypnotic actions in HCN1 knockout mice; etomidate had no effect on HCN1 channels and its ability to evoke a LORR was unaltered in HCN1 knockout mice whereas propofol selectively inhibits HCN1 subunits ( xref ; xref ; xref ) and we found a significant decrease in sensitivity of HCN1 knockout mice to hypnotic effects of propofol."
19158287