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BAP1 inhibits HSF1. 6 / 6
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"BAP1 represses the transcriptional activity of HSF1."
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"As the data above has confirmed that BAP1 inhibits the transcriptional activity of HSF1, we selected genes that are downregulated by HSF1 KD for enrichment analysis."
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"Furthermore, RT-qPCR and HSF1 ChIP-qPCR analysis with several classical genes (ATF4 and CREB5) of TNF signaling pathway indicated that BAP1 represses their expression via HSF1 (Supplementary Fig. S2C-D)."
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"To delve deeper into how BAP1 suppresses HSF1 activity through protein-protein interaction (PPI) with HSF1, we proceeded to construct truncations of HSF1 based on its major functional domains (Fig. 3E)."
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"Additionally, EX-527 treatment attenuated the upregulation of HSF1 activity induced by BAP1 deletion (Fig. 6B)."
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"However, these interrogations do not undermine our conclusion that BAP1 inhibits HSF1 transcriptional activity independently of its enzymatic activity.As previously stated, the significance of BAP1 in maintenance of genomic integrity, DNA damage repair, cellular metabolism, and cell death is relatively well-established [27–30]."
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