IndraLab

Statements

OTUD4 inhibits CDK1. 2 / 2
| 2
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"MG132 (an inhibitor of the ubiquitin-proteasome pathway) dramatically blocks the downregulation of CDK1 caused by OTUD4 knockdown (Fig. 4A), suggesting that OTUD4 protects CDK1 from proteasome-dependent degradation."
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"Next, our results corroborated that FGFR1 interference exacerbated the CDK1 downregulation caused by OTUD4 knockdown, and FGFR1 may maintain CDK1 protein stability by stabilizing the CDK1-cyclinB1 complex (Fig. 5J, K)."
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