IndraLab

Statements

AR activates EP300. 6 / 6
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"Phosphorylation of AR at Ser81 (AR pSer81) also enhances the recruitment of key co-activators – for example, the histone acetyltransferase p300 and BRD4 – which assists in releasing P-TEFb to initiate a positive feedback loop that maintains transcription of AR target genes [105,106]."
40163908
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"Consistently, in CRISPR-based dependency maps (DepMap), p300 ranks as the most essential histone acetyltransferase in AR-driven prostate cancer cells, implying a pivotal role of p300/H2BNTac on prostate cancer cell viability.Notably, about half of the AR enhancers were co-occupied by p300 in prostate cancer cells, which was deterministic of stronger transcriptional activation evidenced both by higher accessibility and subsequent recruitment of the mediator and RNA polymerase II complexes."
38586029
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"AR S81 phosphorylation has been reported to enhance binding of the histone acetyltransferase EP300 (p300), suggesting that p300 binding and subsequent histone acetylation may drive a positive feedback loop through increased BRD4 recruitment, a subsequent increase in P-TEFb recruitment and further AR S81 phosphorylation."
28062857
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"CBP and p300 increases AR transactivation of the AR in response to androgen or IL-6 (Fronsdal et al., 1998; Debes et al., 2002)."
20541699
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"Taking these big data together, we further supported and refined the previous theory that AR activates gene transcription by binding to distal enhancers and recruiting P300 for chromatin acetylation .2."
39091838
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"Expression of the coactivators steroid receptor coactivator-1, receptor-associated coactivator-3, and p300 stimulated both agonist-dependent and -independent activation by AR."
11981028