IndraLab

Statements

USP12 inhibits AKT. 4 / 4
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"WDR48 and USP12 Negatively Regulate Akt Signaling and Promote Apoptosis."
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"As knockdown of WDR48 and USP12 increased Akt activation, we next tested whether WDR48 and USP12 could potentiate the suppression of Akt signaling by PHLPP1."
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"Thus, these results suggest that WDR48 and USP12 negatively regulate Akt signaling and thereby induce apoptosis in conjunction with PHLPP1."
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"Because PHLPP1 is a potent negative regulator of the PI3-kinase and Akt pathway, we hypothesized that WDR48 and USP12 might suppress Akt signaling by stabilizing PHLPP1."
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