IndraLab

Statements



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"Our findings suggest that changes in the kinetics of activation of the IKs channel may predispose to arrhythmic risk in patients who harbor KCNQ1 mutations that are associated with a relatively mild effect on ion channel current and QTc duration."

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"Current activation becomes progressively slower as more KCNE1 subunits are added into the KCNQ1 ion channel tetramer compared with KCNQ1 alone ( xref , right to left panels)."

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"Although KCNQ1 alone can form functional ion channels on the plasma membrane, KCNQ1 is believed to form an ion channel complex with auxiliary subunit KCNE proteins ( xref ; xref ; xref )."