IndraLab

Statements

KCNQ1 binds ion channel. 6 / 6
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"Our findings suggest that changes in the kinetics of activation of the IKs channel may predispose to arrhythmic risk in patients who harbor KCNQ1 mutations that are associated with a relatively mild effect on ion channel current and QTc duration."
20662986
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"Although KCNQ1 alone can form functional ion channels on the plasma membrane, KCNQ1 is believed to form an ion channel complex with auxiliary subunit KCNE proteins ( xref ; xref ; xref )."
22042987
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"Current activation becomes progressively slower as more KCNE1 subunits are added into the KCNQ1 ion channel tetramer compared with KCNQ1 alone ( xref , right to left panels)."
32581825
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"As the Kv7.1 ion channel formed by the KCNQ1 gene requires tetramerization to function, in-frame pathogenic variants which are expressed at the RNA and protein level can potentially result in a more severe phenotype by interfering with the co-assembly of wildtype proteins (dominant-negative effect)."
36721196
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"KCNE4 is one of the subunits of voltage-gated potassium ion channels, which can interact with KCNQ1 channels to form KCNQ1/KCNE4 ion channel complexes and participate in intracellular signal transduction."
39118175
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"Coefficient a versus hKCNE1 expression level : Although KCNQ1 alone can form functional ion channels on the plasma membrane, KCNQ1 is believed to associate with auxiliary subunit KCNE proteins 20–22 t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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