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USP22 activates SNAI1. 4 / 4
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"Moreover, the deficiency of USP22 partly reversed the upregulation of Snail1 induced by HG ( Fig. 5 E)."
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"WB showed that USP22 overexpression increased the protein level of Snail1 compared with those in NG and HG, whereas Snail1 knockdown reversed the increase in Snail1 caused by USP22 overexpression ( Fi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results indicated that USP22 deficiency reversed renal EMT and TIF in diabetic kidneys by blocking the Snail1 signaling pathway (see Fig. 11 )."
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"According to the results of previous studies, USP22 can induce EMT by regulating TGF-beta1 in lung cancer cells [XREF_BIBR], and elevated USP22 expression can promote EMT by up-regulating ZEB1 and Snail in pancreatic cancer cells though a process that involves focal adhesion kinase (FAK) signaling [XREF_BIBR]."
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