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NAC inhibits CASP1. 42 / 42
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"Caspase-1 activity was directly measured and shown to be enhanced at 6 h after OGD/R but was inhibited by addition of NAC (p < 0.05)."
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"NAC can significantly reverse rising trend of P2X7R and key proteins in HG group and inhibit NLRP1/caspase-1 mediated neuronal injury (Figures 5A–F)."
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"It was reported that caspase-1 can be activated by ROS production, on the contrary to this, anti-oxidant NAC can inhibit caspase-1 activation [41] ."
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"Importantly, NAC treatment blocked the accumulation of caspase-1 induced by either MG132 or CVB3 infection, and the decline of procaspase-1 was coincided with the significantly reduced production of v[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Levels of NLRP3, ASC, and caspase-1 p20 were significantly upregulated after OGD/R (p < 0.05), while levels of NLRP3, ASC, and cleaved caspase-1 were significantly downregulated by the addition of NAC (p < 0.05)."
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"Indeed, the antioxidant NAC is able to inhibit caspase-1 activation in response to various NLRP3 stimuli (e.g., LPS/ATP, LPS/nigericin, or LPS/silica) [52]."
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"Notably, NAC effectively blocked the GCN5L1 overexpression mediated upregulation of NLRP3, caspase 1, IL18, and IL1b (XREF_FIG)."
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"L-MP-induced caspase-1 activation and IL-1beta release were also abrogated by NAC."
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"Caspase-1 activation in the macrophages was markedly inhibited by treatment with three inhibitors, namely, KCl (a potassium channel inhibitor), NAC (an ROS inhibitor), and CA074-ME (a cathepsin B inhibitor)."
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"NAC and/or CGA Inhibited the TLR4/NLPR3/IL-1beta and Caspase-1/GSDMD Signaling in Cp-Induced Nephrotoxicity."
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"The results showed that NAC could partially inhibit the activation of CASP1 and the cleavage of GSDMD caused by LPS+ATP treatment."
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"Additionally, in LPS stimulated PMs, NAC treatment abolished caspase-1 activation (XREF_FIG) and IL-1beta secretion (XREF_FIG) induced by CGI-58 knockout."
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"Finally, Rip2 -/- BMDM treated with the ROS scavenger N-acetyl-L-cysteine (NAC) had reduced caspase-1 activation and IL-18 production compared to WT cells (XREF_FIG)."
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"NAC reduced Cd induced increases in ROS, NLRP3, Caspase-1, Heme oxygenase-1(HO-1), superoxide dismutase (SOD2), and increased mitochondrial function."
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"In this work, NAC inhibited the SARS-CoV-2 mosaic (S-E-M)-induced CASP1 activation that is necessary to cleave and activate gasdermin D, therefore it is reasonable to think that N-acetylcyste inhibits SARS-CoV-2 mosaic (S-E-M) -induced Gasdermin D activation."
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"Our study shows that NAC reduced caspase 1, caspase 3, calpain 1, iNOS and eNOS in CIN but that histopathologically and biochemically it did not establish adequate improvement in kidney functions."
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"Two antioxidants, NAC and quercetin, suppressed maturation of IL-1β and IL-18, activation of caspase-1 in U937 cells treated with MSU crystals ( Fig. 4 D)."
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"As shown by western blot analysis, the expressions of NLRP3, pro-caspase-1, cl-caspase-1 and IL-1β were notably inhibited by NAC in diabetic cornea ( Fig. 3 B–C)."
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"Most importantly, NAC treatment could reverse Icariside I -induced caspase-1 maturation and IL-1beta production when stimulated with ATP."
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"The antioxidant NAC inhibited caspase-1 activation and IL-1beta secretion (XREF_FIG)."
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"In addition, N-acetylcysteine (NAC), a scavenger of reactive oxygen species (ROS),can effectively inhibit caspase-1 activation and the production of mature IL1-β ( Jabir et al., 2015 )."
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"Addition of extracellular potassium or the reactive oxygen scavenger NAC, both of which can prevent activation of the NLRP3 inflammasome, did not prevent activation of caspase-1 in response to infection with either the T3SS or the WT Yersinia strains (XREF_FIG and data not shown)."
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"We therefore examined Ulk1 -/- BMDCs and found that they also have increased caspase-1 activation following IAV infection and this increased caspase-1 activation was suppressed by NAC treatment (XREF_FIG)."
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"Our previous study shows that NAC inhibits CVB replication by inhibiting the activation of caspase-1, which facilitates CVB replication by an unknown mechanism [16]."
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"Given that caspase-1 is required for the maturation of both IL-1β and IL-18, the reduced IL-1β and IL-18 implies that caspase-1, its precursor or active form, is down-regulated by NAC treatment.To thi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As expected, when stimulated with nigericin, NAC treatment reversed epimedin B-induced caspase-1 maturation or IL-1β production (Figures 6F,G)."
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"However, prior treatment with ROS scavenger NAC attenuated the activity of caspase-1 activity and production of IL-1β induced by nicotine (Figure 7)."
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"As shown in Fig. 4 E, NAC treatment remarkably reduced the activity of caspase-1, indicating that NAC directly inhibits the activity of caspase-1.To provide evidence that caspase-1 plays a role in CVB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that the synthesis of 3D pol of CVB3 was almost completely blocked in the cells with the knockdown of procaspase-1 ( Fig. 4 F and G), indicating that caspase-1 is required for CVB3 replicatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Figure 2A, a NAC concentration of 5 mM was sufficient to completely suppress caspase-1 activation in cells treated with CPPD (IC = 625 μM)."
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"Similarly, ROS scavenger NAC and psoralidin co-treatment suppressed caspase-1 maturation and IL-1β production when the inflammasome is activated."
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"Most importantly, when LPS-induced BMDM was treated with IXN and then stimulated with ATP, NAC pretreatment eliminated the increase IL-1β production and caspase-1 maturation ( Fig. 5 D)."
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"However, as shown in Figure 2B, a NAC concentration of just 500 μM was sufficient to completely suppress caspase-1 activation in MSU-treated cells (IC = 31.25 μM)."
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"And ROS scavenger NAC attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration and invasion."
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"In contrast, NAC inhibited caspase-1 activation in response to TLR signaling (XREF_FIG)."
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"Additionally, NAC treatment increased endogenous antioxidant molecules such as glutathione and thioredoxin-2 and suppressed caspase-3, calpain, and caspase-1 activation."
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"During PRRSV infection, the enhanced caspase-1 activity was inhibited either by NAC or by caspase-1 inhibitor YVAD-CHO (Fig. 6F)."
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"NAC and YVAD-CHO suppressed GP5-activated caspase-1 activity (Fig. 6M)."
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"BAPTA-AM, NAC, and WOR also inhibited significantly the caspase-1 enzymatic activity in PMA-stimulated HMC-1 cells ( P < 0.05, Fig. 6 B)."
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"DPI and NAC strongly inhibited caspase-1 processing, whereas BAY-117082 had little impact on cells stimulated with S100A8, S100A9, or LPS in the presence of ATP (XREF_FIG)."
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"The increase of ROS generation in THP-1 cells was abolished by DPI, NAC, which down-regulated caspase-1 activation as well."
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"Motivated by our finding that NAC inhibits the activity of caspase-1, we asked the question if NAC also shows inhibitory effect on viral proteases, since viral proteases, like caspase-1, are also cyst[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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