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NAC inhibits CASP1. 18 / 18
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"Additionally, NAC treatment increased endogenous antioxidant molecules such as glutathione and thioredoxin-2 and suppressed caspase-3, calpain, and caspase-1 activation."
34504417
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"We therefore examined Ulk1 -/- BMDCs and found that they also have increased caspase-1 activation following IAV infection and this increased caspase-1 activation was suppressed by NAC treatment (XREF_FIG)."
23525089
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"Most importantly, NAC treatment could reverse Icariside I -induced caspase-1 maturation and IL-1beta production when stimulated with ATP."
33573688
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"In contrast, NAC inhibited caspase-1 activation in response to TLR signaling (XREF_FIG)."
24043892
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"And ROS scavenger NAC attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration and invasion."
30796177
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"The antioxidant NAC inhibited caspase-1 activation and IL-1beta secretion (XREF_FIG)."
25367573
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"Finally, Rip2 -/- BMDM treated with the ROS scavenger N-acetyl-L-cysteine (NAC) had reduced caspase-1 activation and IL-18 production compared to WT cells (XREF_FIG)."
25254654
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"However, prior treatment with ROS scavenger NAC attenuated the activity of caspase-1 activity and production of IL-1β induced by nicotine (Figure 7)."
31835256
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"Addition of extracellular potassium or the reactive oxygen scavenger NAC, both of which can prevent activation of the NLRP3 inflammasome, did not prevent activation of caspase-1 in response to infection with either the T3SS or the WT Yersinia strains (XREF_FIG and data not shown)."
20478539
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"Additionally, in LPS stimulated PMs, NAC treatment abolished caspase-1 activation (XREF_FIG) and IL-1beta secretion (XREF_FIG) induced by CGI-58 knockout."
24703845
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"NAC can significantly reverse rising trend of P2X7R and key proteins in HG group and inhibit NLRP1/caspase-1 mediated neuronal injury (Figures 5A–F)."
34093185
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"Levels of NLRP3, ASC, and caspase-1 p20 were significantly upregulated after OGD/R (p < 0.05), while levels of NLRP3, ASC, and cleaved caspase-1 were significantly downregulated by the addition of NAC (p < 0.05)."
32891159
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"Caspase-1 activity was directly measured and shown to be enhanced at 6 h after OGD/R but was inhibited by addition of NAC (p < 0.05)."
32891159
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"L-MP-induced caspase-1 activation and IL-1beta release were also abrogated by NAC."
31649305
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"Caspase-1 activation in the macrophages was markedly inhibited by treatment with three inhibitors, namely, KCl (a potassium channel inhibitor), NAC (an ROS inhibitor), and CA074-ME (a cathepsin B inhibitor)."
30217146
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"Notably, NAC effectively blocked the GCN5L1 overexpression mediated upregulation of NLRP3, caspase 1, IL18, and IL1b (XREF_FIG)."
33680286
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"DPI and NAC strongly inhibited caspase-1 processing, whereas BAY-117082 had little impact on cells stimulated with S100A8, S100A9, or LPS in the presence of ATP (XREF_FIG)."
23977231
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"IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor."
17628610