IndraLab

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Parthenolide inhibits CASP1. 18 / 18
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"Parthenolide has also been shown to directly inhibit caspase-1 by alkylation of the enzyme 's p20 subunit [XREF_BIBR]."
27191349
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"Parthenolide inhibits NLRP1, NLRC4, and NLRP3 stimuli by alkylating a number of cysteine residues of caspase-1 thus blocking caspase-1 activation."
33534121
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"Our results disagree with this assertion as we did not find that parthenolide inhibited caspase-1 in response to AIM2 stimulation."
22216309
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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."
24296756
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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65/RelA and caspase-1 via alkylation xref ."
24296756
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"XREF_BIBR It was thought to be an NFkappaB inhibitor through selective inhibition of kappaB kinase beta (IKKbeta) kinase activity; however, in addition to its effects on NFkappaB activation, parthenolide has now been shown to inhibit activation of caspase-1 in response to NLRP3, NLRP1, and NLRC4 stimulation."
25653548
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"Parthenolide and Bay 11-7082 directly inhibit activation of the protease caspase-1 to inhibit the various inflammasomes in macrophages [167]."
34059091
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"Our results disagree with this assertion as we did not find that parthenolide inhibited caspase-1 in response to AIM2 stimulation."
22216309
eidos
"Parthenolide inhibits caspase-1 activation , however , has poor solubility and bioavailability ."
33280442
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"Parthenolide has previously been shown to inhibit NLRC4 dependent caspase-1 activation 15, although it did not do so in these experiments (XREF_FIG)."
25686105
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"Juliana et al. [64] reported that parthenolide inhibited the activity of inflammasomes in primary macrophage cell cultures by directly inhibiting caspase-1, which led to the downregulation of IL-1β and IL-18 level."
26090236
eidos
"Parthenolide is another vinylsulfone that blocks caspase-1 , and therefore prevents caspase-1 activity in response to the activation of NLRP3 , NLRC4 , and AIM2 inflammasomes [ 113 ] ."
33803783
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"The effect of parthenolide on the spectrum of inflammasomes implies that it acts on a common component and, accordingly, it has been shown that parthenolide is a direct inhibitor of caspase-1, causing alkylation of caspase-1 on a number of cysteine residues."
25653548
sparser
"However, the previous study xref did not test AIM2 activation so perhaps parthenolide only inhibits caspase-1 in response to NLRP3 or NLRC4 activation."
22216309
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"XREF_BIBR have shown that parthenolide directly inhibits caspase-1 by alkylation of certain cysteine residues."
22216309
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"Notably, the combination of chloroquine and 6-AN triggered activation of the NF-kB and inflammasome pathways in a TSC2 dependent manner, and parthenolide 16, which inhibits both NF-kB and caspase-1, rescued proliferation under these conditions."
24296756
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"Since parthenolide inhibits both NF-kappaB and caspase-1 activation, we determined whether this result is due predominantly to inflammasome inhibition by treating THP-1 cells with Bay 11-7082, which selectively inhibits the NLRP3 inflammasome independently of its effect on NF-kappaB activity."
20434582
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"Juliana et al. xref have shown that parthenolide directly inhibits caspase-1 by alkylation of certain cysteine residues."
22216309