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LDLR binds LRP1. 43 / 43
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"Though studies have shown ApoE ability to bind Aβ [ xref ] and reduced Aβ clearance in ApoE KO astrocytes [ xref ], it has been observed that ApoE affects Aβ uptake because of its competitive binding to LRP1 and LDLR, rather than directly binding Aβ [ xref ]."
34943002
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"ApoE4 has marginally greater receptor-binding capability than ApoE3, but ApoE2 is defective with only 2% and 40% binding activity to the LDLR and LRP, respectively."
22645694
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"Heterogeneous lipoprotein(a) size isoforms differ by their interaction with the low density lipoprotein receptor and the low density lipoprotein receptor related protein/ alpha-2-macroglobulin recepto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7789983
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"This process involves: (1) the binding of a Wnt ligand to the extracellular cysteine rich domain on the transmembrane Frizzled receptor, (2) phosphorylation/activation of the protein disheveled by low-density lipoprotein receptor-related protein (LDLR-LRP) -5 or -6 co-receptors, (3) blocking of glycogen synthase kinase-3β activity (GSK-3β) by sequestering GSK-3β via the inhibitory protein frequently rearranged in advanced T cell lymphomas (Frat), and (4) inactivation of the “destruction complex” resulting in decreased phosphorylation and down-regulating proteasomal degradation of β-catenin [ xref , xref , xref , xref ]."
33333818
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"Inclusion of excess GST–RAP during ligand blotting experiments with 125 I -labeled GST–RAP abolished binding to bot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9540794
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"For example, interactions with the LDL receptor and Lrp1 support the M6PR-independent delivery of cathepsin D to lysosomes ( xref ), whereas glucocerebrosidase, whose loss causes a lysosome storage disorder known as Gaucher’s disease, is routed through a LIMP-2–dependent mechanism ( xref )."
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"The different rates of uptake of CRLPs oxCRLPs and pCRLPs by macrophages demonstrated here, therefore, could be explained by effects on interaction with the LDLr and the LRP caused by differences both in the conformation of apoE and in the number of apoE molecules able to bind to the receptors, even though the total amount of apoE associated with the particles is not changed."
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"This requirement for calcium is a characteristic feature of binding of ligands to the LDL receptor or LRP [38] ."
9540794
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"The contribution of the exposure of apoE molecules on the surface of triglyceride-rich particles sensitive both to lipolysis and plasma triglyceride content to the interaction with LDL receptor and LRP is emphasized."
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"23 Lack of the putative LDLR binding domains in apoB100-beta may also prevent the secretion of newly packaged but underlipidated particles by enhancing the degradation of apoB through enhanced interactions between apoE and LDLR and LRP."
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"These data indicate that hypercholesterolemia in Ovx rats is associated with a reduction of hepatic LDL-R and Lrp1 gene expression."
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"The domains homologous to the ligand-binding domain of the LDL receptor contain highly conserved disulfide bonds and negative charges, and, like the LDL receptor, LRP binds calcium with high affinit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, the particular cell-type specific interaction of the LDLR and Lrp1 as well as between Lrp1 and Lrp 4, 5, and 6 will need to be explored by bone-cell specific conditional targeting of each receptor."
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"However, ligand binding to LRP1, a member of LDLR family, transactivates the Trk receptors through an SFK-dependent pathway in PC12 cells and neurons [ xref ], demonstrating that apolipoprotein E-receptors have neurotrophic activity that is dependent on Trk receptor transactivation."
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"The use of mice deficient in SMC LRP (LRP smc−∕− ) associated with LDLR knockout (LDLR −∕− ) resulted in a severe vSMC proliferation within the aorta, disruption of elastic laminae, and enhancement of atherosclerosis, suggesting that vSMC LRP plays an important atheroprotective role via clearance capacities not limited to LDL endocytosis alone (Boucher et al., xref )."
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"This conclusion is supported by comparison of normal and LDL receptor negative human fibroblasts.Although LPL binds directly to both LRP and LDL receptors, there is evidence in vitro to suggest that d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ApoE4 has higher affinity for VLDL and IDL than HDL compared to apoE3, resulting in more efficient delivery of cholesterol-containing lipoproteins to the liver, while the apoE2 is defective in LDLR an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15585207
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"Another interesting finding was that human rhinoviruses of the minor serotype group, which are known to enter host cells via binding to LDLR or LRP [58] , also bind to the VLDLR receptor as assessed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9862168
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"In contrast, apoE2 binds to LDLR and LRP1, but not syndecan-1, with lower affinity, implying that apoE on TRLs competes with Lp(a) for LDLR and LRP1-mediated hepatic clearance."
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"ApoE4 has higher affinity for VLDL and IDL than HDL compared to apoE3, resulting in more efficient delivery of cholesterol containing lipoproteins to the liver, while the apoE2 is defective in LDLR an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15585207
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"In addition, apoE may compete with Aβ for binding to common cell surface receptors, LRP1 and LDLR."
28434655
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"We conclude that in vivo the APOE*2 variant is completely defective in LDL receptor binding but not in binding to LRP, whereas for the APOE*3-Leiden mutant both LRP and LDL receptor binding activity are only mildly affected."
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"None of the LDLa repeats of LRAD3 contains all of the necessary acidic amino acids that are required for generating an acidic pocket capable of docking lysine side chains that protrude from certain LDL receptor family member ligands, such as the receptor associated protein (RAP) ( xref ) ( xref ), suggesting that potential ligands are likely to be distinct from those that interact with the LDL receptor or LRP1."
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"Similarly, soluble forms of LDLR and LRP1 as a result of cell surface proteolytic cleavage have been reported, with the suggestion that these proteins also antagonize the actions of cell surface LDLR and LRP1 ( xref , xref )."
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"Another effect of reduced recycling of apoE4 is due to the tight binding of apoE4 to LDLR and LRP1 in the endosomal compartment [ xref ], which in turn affects the interaction of the amyloid precursor protein (APP) and LRP1 that is crucial for the generation of Aβ [ xref , xref ]."
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"Finally, siRNA-CaP-rHDL was prepared by incubating siRNA-CaP-LNC with apolipoprotein E3 (ApoE3), which was previously confirmed to be responsible for binding to low-density lipoprotein receptor (LDLR) and low-density lipoprotein receptor-related protein 1 (LRP1) that are expressed in the BBB, blood–brain tumour barrier (BBTB) and glioblastoma cells xref xref xref xref xref ."
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"This requirement for calcium is a characteristic feature of binding of ligands to the LDL receptor or LRP [38]."
9540794
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"ApoCI is an inhibitor of LPL activity, and inhibits the binding of VLDL to LDL-receptor related protein (LRP), xref , xref as well as the apoE-mediated binding of VLDL to the LDLR and the LRP. xref , xref ApoCI is a potent activator of lecithin:cholesterol acyltransferase (LCAT), xref , xref leading to elevated HDL-cholesterol ester concentrations. xref xref – xref In apoCI-deficient mice, the primary metabolic defect is an impaired VLDL uptake by the liver in vivo. xref Interestingly, whereas overexpression of human APOC1 in transgenic mice predominantly inhibits the uptake of VLDL by the liver, the absence of endogenous apoCI in mice appears to have the same effect, although to a lesser extent."
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"The first identified member of the LDL receptor family, LDLR, is expressed on the cell surface of hepatocytes and binds LDL particles through Apolipoprotein B (ApoB); similarly, LDLR and LRP1 bind ApoE on chylomicron remnants and VLDL particles [XREF_BIBR]."
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"One may postulate that when apoE is present on larger chylomicron remnants and VLDL particles, it competes for binding to LDLR and LRP1, thereby slowing their clearance and leading to higher LDL-C and Lp(a) levels."
28062489
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"In human populations, there are three major allelic variants of apoE, involving arginine-cysteine substitutions at positions 112 and 158, which alter the affinity for binding to the LDLR and LRP."
15585207
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"The fact that both Dab2 and ARH increased the size of CCPs relative to CCPs in which AP2 is the predominant adaptor (i.e., under conditions of TfnR overexpression) might reflect the need to accommodate the very large ligands bound by LDLR and LRP ( xref ) (i.e., LDL particles, d∼22 nm and α2-macroglobulin, d∼18.5 nm; xref ), respectively."
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"However, the particular cell-type specific interaction of the LDLR and Lrp1 as well as between Lrp1 and Lrp 4, 5, and 6 will need to be explored by bone-cell specific conditional targeting of each receptor."
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"We first confirmed the physical interaction between LDLR, APP, APLP2 and LRP1 with PCSK9 by co-immunoprecipitation and immunoblotting experiments."
28495363
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"One of the functional consequences of the reduced binding to LDL-R and LRP1 of E2 could be higher detectable concentrations of ApoE."
27755538
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"This complex can bind to low-density lipoprotein receptor (LDLR) and LRP1, internalize, and accumulate into endosomes within synapses (Bilousova et al., xref )."
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"The present study showed that CCK also increased plasma apoE, a protein that aids chylomicron remnant binding to LDLR and LRP for cellular endocytosis xref ."
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"In the Wnt “on” state, Wnt glycoproteins bind to Frizzled (FZD) and low-density lipoprotein receptor-related protein (LRP), thereby recruiting the disheveled (DVL) to the cell membrane [31]."
32758292
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"This is important since apoE3 and apoE4 can bind to LDLR and LRP1, whereas apoE2 does not ( xref )."
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"Ligand blot analysis demonstrated that pigeon beta VLDL bound to both the LDL receptor and LRP."
7757290
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"ApoE mediates binding of remnant lipoproteins to LDLR and LRP."
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"For example, the E2 isoform binds LDL-R and LRP1 with a reduced efficiency compared to the other isoforms (≤2% compared to E3; E4 has affinities comparable to E3) [ xref , xref ]."
27755538
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"It is unclear whether the apoC-III 0a and apoC-III 0b glycoforms affect the affinity of TRLs for SDC1, but in previous studies the absence or presence of murine apoC-III 0a on TRLs did not seem to affect the capacity of SDC1 to mediate TRL clearance. xref This thus suggests no preferential binding of apoC-III 0a to HSPGs. xref Combined, these observations support the idea that the apoC-III 0a glycoform (or murine apoC-III) is a very potent inhibitor of TRL binding to LDLR and LRP1 and shifts clearance of apoC-III 0a bearing TRLs to SDC1 by default (and not by greater affinity)."
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