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LDLR binds LRP1. 33 / 34
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"This complex can bind to low-density lipoprotein receptor (LDLR) and LRP1, internalize, and accumulate into endosomes within synapses (Bilousova et al., xref )."
32362813
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"However, ligand binding to LRP1, a member of LDLR family, transactivates the Trk receptors through an SFK-dependent pathway in PC12 cells and neurons [ xref ], demonstrating that apolipoprotein E-receptors have neurotrophic activity that is dependent on Trk receptor transactivation."
25233900
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"However, the particular cell-type specific interaction of the LDLR and Lrp1 as well as between Lrp1 and Lrp 4, 5, and 6 will need to be explored by bone-cell specific conditional targeting of each receptor."
29507818
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"For example, interactions with the LDL receptor and Lrp1 support the M6PR-independent delivery of cathepsin D to lysosomes ( xref ), whereas glucocerebrosidase, whose loss causes a lysosome storage disorder known as Gaucher’s disease, is routed through a LIMP-2–dependent mechanism ( xref )."
26975848
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"One may postulate that when apoE is present on larger chylomicron remnants and VLDL particles, it competes for binding to LDLR and LRP1, thereby slowing their clearance and leading to higher LDL-C and Lp(a) levels."
28062489
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"Finally, siRNA-CaP-rHDL was prepared by incubating siRNA-CaP-LNC with apolipoprotein E3 (ApoE3), which was previously confirmed to be responsible for binding to low-density lipoprotein receptor (LDLR) and low-density lipoprotein receptor-related protein 1 (LRP1) that are expressed in the BBB, blood–brain tumour barrier (BBTB) and glioblastoma cells xref xref xref xref xref ."
28489075
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"This is important since apoE3 and apoE4 can bind to LDLR and LRP1, whereas apoE2 does not ( xref )."
32849270
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"Furthermore, bioinformatics analysis suggested an interaction between apoE and low-density lipoprotein receptor-related protein 1 (LRP1)."
37310025
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"Though studies have shown ApoE ability to bind Aβ [ xref ] and reduced Aβ clearance in ApoE KO astrocytes [ xref ], it has been observed that ApoE affects Aβ uptake because of its competitive binding to LRP1 and LDLR, rather than directly binding Aβ [ xref ]."
34943002
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"Moreover, the interaction between ApoE and LRP4, LDL receptor, and Lrp1 can facilitate the uptake of Aβ by astrocytes, with LRP4 demonstrating superior efficacy at the intracellular level in comparison to the latter two receptors [110]."
38521950
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"None of the LDLa repeats of LRAD3 contains all of the necessary acidic amino acids that are required for generating an acidic pocket capable of docking lysine side chains that protrude from certain LDL receptor family member ligands, such as the receptor associated protein (RAP) ( xref ) ( xref ), suggesting that potential ligands are likely to be distinct from those that interact with the LDL receptor or LRP1."
21795536
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"The first identified member of the LDL receptor family, LDLR, is expressed on the cell surface of hepatocytes and binds LDL particles through Apolipoprotein B (ApoB); similarly, LDLR and LRP1 bind ApoE on chylomicron remnants and VLDL particles [XREF_BIBR]."
28057414
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"In contrast, apoE2 binds to LDLR and LRP1, but not syndecan-1, with lower affinity, implying that apoE on TRLs competes with Lp(a) for LDLR and LRP1-mediated hepatic clearance."
28360338
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"ApoE, the primary lipid and cholesterol transporters in the central nervous system, facilitate the transport of lipids by binding to LDLR and LRP1 [ xref ]."
38137453
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"It facilitates lipid distribution to neurons in the central nervous system by binding to APOE cell surface receptors LDLR (the low-density lipoprotein receptor) and LRP1 (LDL Receptor Related Protein 1) [ xref ]."
38790930
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"It is unclear whether the apoC-III 0a and apoC-III 0b glycoforms affect the affinity of TRLs for SDC1, but in previous studies the absence or presence of murine apoC-III 0a on TRLs did not seem to affect the capacity of SDC1 to mediate TRL clearance. xref This thus suggests no preferential binding of apoC-III 0a to HSPGs. xref Combined, these observations support the idea that the apoC-III 0a glycoform (or murine apoC-III) is a very potent inhibitor of TRL binding to LDLR and LRP1 and shifts clearance of apoC-III 0a bearing TRLs to SDC1 by default (and not by greater affinity)."
31390883
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"ApoC-I and C-III inhibit the binding of lipoproteins to LRP-1 and LDLR [32]; therefore, decreased levels of ApoC-I and C-III facilitate the binding between lipoprotein and LRP-1 and LDLR."
36923709
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"Similarly, low-density lipoprotein receptor–related protein 1 (LRP1) is mainly distributed to the abluminal side of the BBB and serves to Aβ clearance from brain to blood by binding to Aβ."
34990795
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"ApoE mediates lipid transport through interactions with LDLR and LRP1 and subsequent receptor-mediated endocytosis into cells, where the lipids are released and used to support multiple processes such as membrane extension and synaptogenesis [ xref , xref ]."
40275327
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"These data indicate that hypercholesterolemia in Ovx rats is associated with a reduction of hepatic LDL-R and Lrp1 gene expression."
24619822
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"Such an effect of vitronectin was thought to be attributable to its ability to bridge interaction between endothelial cell basement membrane GAGs and the low-density lipoprotein receptor (LRP-1) bound by the vitronectin binding partner PAI-1 on the surface of circulating neutrophils."
36936905
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"For example, the E2 isoform binds LDL-R and LRP1 with a reduced efficiency compared to the other isoforms (≤2% compared to E3; E4 has affinities comparable to E3) [ xref , xref ]."
27755538
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"One of the functional consequences of the reduced binding to LDL-R and LRP1 of E2 could be higher detectable concentrations of ApoE."
27755538
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"Bands indicating APOE bound LDLR and LRP1 were almost invisible."
35847502
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"Another effect of reduced recycling of apoE4 is due to the tight binding of apoE4 to LDLR and LRP1 in the endosomal compartment [ xref ], which in turn affects the interaction of the amyloid precursor protein (APP) and LRP1 that is crucial for the generation of Aβ [ xref , xref ]."
19695092
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"We first confirmed the physical interaction between LDLR, APP, APLP2 and LRP1 with PCSK9 by co-immunoprecipitation and immunoblotting experiments."
28495363
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"Thanks to its ability of interaction with the LDL receptor and LRP1 protein (LDL receptor-related protein), apoE plays a major role in transport and metabolism of plasma cholesterol and triglycerides."
23701968
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"However, the particular cell-type specific interaction of the LDLR and Lrp1 as well as between Lrp1 and Lrp 4, 5, and 6 will need to be explored by bone-cell specific conditional targeting of each receptor."
29507818
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"In addition, apoE may compete with Aβ for binding to common cell surface receptors, LRP1 and LDLR."
28434655
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"Recombinant ApoE3 was utilized because its C-terminal domain plays a role in lipid binding, while its N-terminus interacts with LDLR and LRP1."
39695696
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"As PBCA nanoparticles require specific binding of LDLR and LRP1 to trigger clathrin-dependent transcytosis and thus cross the BBB, the decreased expression of these receptors and clathrin in brain endothelial cells of aged mice ( xref ) may underlie the molecular basis of the reduced blood–brain transport of nanocarriers."
38252832
sparser
"Heterogeneous lipoprotein(a) size isoforms differ by their interaction with the low density lipoprotein receptor and the low density lipoprotein receptor related protein/ alpha-2-macroglobulin recepto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7789983
sparser
"Similarly, soluble forms of LDLR and LRP1 as a result of cell surface proteolytic cleavage have been reported, with the suggestion that these proteins also antagonize the actions of cell surface LDLR and LRP1 ( xref , xref )."
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