IndraLab

Statements

KCNH1 inhibits apoptotic process. 6 / 6
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"Suppression of Eag1 increased the induction of apoptosis (Q4 and Q2) caused by TMZ (XREF_FIG)."
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"For instance, inhibitors of Kv10.1 and hERG channels have been shown to reduce proliferation and induce apoptosis in BC cells (Peretti et al., 2019)."
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"For example, the use of Eag blockers, such as imipramine and clofilium, increased the proportion of SKOV-3 cells undergoing early apoptosis, whereas treatment with the HERG channel specific blockers, E-4031 and ergtoxin, affected the cell cycle, resulting in the block of OC cells in the S phase (XREF_TABLE and XREF_FIG) [XREF_BIBR]."
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"HERG blockers inhibit the proliferation at S and G2/M phase while Eag blocker impramine increases early apoptosis in ovarian cancer cells with no effect on cell cycle."
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"In addition, silencing of Eag1 caused 11% induction of the rate of apoptosis in comparison with scramble (P = 0.013; XREF_FIG)."
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"Furthermore, Eag1 silencing increased the rate of rotenone induced apoptosis by 33% compared with control group as revealed by Hoechst assay (P = 0.025; XREF_FIG)."
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