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OTUB1 activates ERK. 5 / 5
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"Western-blot assays indicated that overexpression of OTUB1 notably enhanced the activation of AKT and ERK signaling pathways (Fig. 6a–c), which is consistent with previous reports [22, 23]."
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"Immunoblotting showed that OTUB1 overexpression enhanced RACK1 and led to the activation of the Akt and ERK/FAK pathways in HCC cells."
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"Therefore, OTUB1 significantly increased multiple oncogenes expression and activated PI3K/AKT and FAK/ERK signaling in a RACK1-dependent manner in HCC."
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"Besides, when we blocked PI3K/AKT and/or MEK/ERK signaling by its specific inhibitor MK2206 and PD98059, the promotive effect of OTUB1-induced malignant behavior of HCC cells was also significantly reversed (Fig. 6d–q), demonstrating that OTUB1 performed the tumor-enhanced effects by effectively activating the AKT and ERK signaling pathway."
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"OTUB1 contributed to HCC progression by activating PI3K/AKT and FAK/ERK signaling in a RACK1-dependent manner."
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