IndraLab

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USP7 activates inflammatory response. 19 / 19
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"Furthermore, USP7 depletion improved lipid accumulation, suppressed oxidative stress, and reduced inflammation in AS mice, which are consistent with previous studies on the role of USP7 in lipid metabolism and inflammation."
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"The administration of p22077, the inhibitor of USP7, attenuated Ang II-induced inducibility and duration of AF, atrial dilatation, connexin dysfunction, atrial fibrosis, atrial inflammation, and atrial oxidase stress, and then inhibited the progression of AF."
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"Besides, study has shown that the expression of USP7 was upregulated in H9C2 cardiomyocytes cultured under hypoxia and in the heart of MI rats, and overexpression of USP7-induced inflammation and apoptosis of cardiomyocytes, leading to aggravation of MI injury."
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"USP7 overexpression aggravated LPS-induced HPMEC apoptosis, inflammation, oxidative stress, and M1 macrophage polarization."
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"Depletion of USP7 reduced inflammatory response during inflammation process (114)."
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"The purpose of this research was to observe the functions and mechanisms of ubiquitin-specific peptidase 7 (USP7) on chondrocytes under tumor necrosis factor alpha- (TNF- α -) induced inflammation."
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"The knockdown of USP7 or its inhibitor decreased chondrocyte proliferation and accelerated apoptosis and inflammatory response under inflammation."
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"Within tumor inflammation, USP7 modulates tumor growth and immune responses by removing ubiquitin tags from key proteins, thereby altering their stability and function [4]."
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"However, another study reported that USP7 promotes chondrocyte proliferation and inhibits apoptosis and tumor necrosis factor-α-induced inflammatory response by inhibiting the BiP-eIF2α-ATF4-CHOP signaling pathway and NF-κB/p65 signaling pathway of endoplasmic reticulum stress [34]."
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"However, whether USP7 contributes to COPD inflammation and mucus hypersecretion through other signaling pathways requires further study."
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"USP7 knockdown reduced inflammation and cell injury during AP progression by inhibiting ATF4-mediated autophagy activation."
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"Genetic deletion of Usp7 or Gzma together with the pharmacological blockade of granzyme B attenuated eosinophilic airway inflammation in vivo."
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"The knockdown or inhibition of USP7 using specific inhibitors was observed to significantly reduce the TNF-alpha-induced inflammatory response of endothelial cells and their adhesion capacity to monocytes."
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"Whereas knockout of USP7 increases the cellular proportion of endothelial cells and potentially attenuates the elevated EndoMT, fibrosis, and inflammation in cardiac tissue of KD mice, consistently with the in vitro experiment observed in HCAECs induced by TGF-β2."
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"Conversely, the overexpression of USP7 was observed to promote the inflammatory response and adhesion capacity of endothelial cells."
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"In this study, USP7 depletion and P5091 were shown to inhibit inflammation in senescent bone marrow-derived macrophages (BMDMs) and promote osteogenic differentiation in aged bone marrow mesenchymal stromal cells (BMSCs)."
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"Therefore, ablation of USP7 improved the AS morphological characteristics in AS mice.3.2 Knockdown of USP7 suppressed inflammation in AS mice."
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"Silencing of USP7 inhibits inflammation and cell apoptosis in ALI mouse."
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"USP7 inhibition has been indicated to limit the inflammatory response in the treatment of acute or chronic inflammation."
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