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"Furthermore, immunoblot analysis of lysates from Hek 293 T cells transfected with K48-Ub, Myc-tagged PIK3C3 fragments showed the ubiquitination of V2 fragment of PIK3C3 was inhibited by Cezanne which indicated that the actual K48-linked ubiquitination lysine residue of PIK3C3 might locate at this fragment (Fig. xref )."