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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP7 activates MAF. 3 / 3

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"The action of USP7 thus promoted Maf transcriptional activity as evidenced by luciferase assays and by the upregulation of the expression of Maf modulated genes."

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"In contrast, another deubiquitinase, USP7, also increased the transcriptional activity of c-Maf, but luciferase activity driven by USP7 was much less affected by mebendazole than luciferase activity driven by USP5."

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"Consistently , USP7 knockdown led to the degradation of Maf in addition to increased levels of polyubiquitination ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...