IndraLab

Statements

USP22 inhibits signal transduction. 4 / 4
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"Knockdown of USP22 can activate STAT1 signaling pathway, inhibit T-cell depletion, and promote the proliferation and activation of NK cells (75)."
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"These results further validated that the tumors with Usp22 overexpression were significantly larger and more aggressive than those in the control group, whereas Usp22 ablation diminished this effect.2.2 USP22 activates the mTORC1 signaling pathway."
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"Conversely, ectopic expression of USP22 reversed this effect by modulating the NF-κB signaling pathway."
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"USP22 can also enhance the telomerase reverse transcriptase (TERT)/p53 signaling pathway [ 65 ] and promote cell proliferation and DNA repair (see Fig. 1 )."
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