IndraLab

Statements


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"This is achieved through the downregulation of anti-apoptotic proteins survivin and cFLIP, which are degraded by the deubiquitinase STAMBPL1."

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"This study demonstrated that TBMS-1 sensitizes cancer cells to the apoptosis effect of TRAIL via STAMBPL1-dependent downregulation of c-FLIP."

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"We previously reported the involvement of STAMBPL1-mediated c-FLIP degradation in TRAIL sensitization and showed that STABMPL1 overexpression reduces c-FLIP ubiquitination [19]."