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AGT inhibits KCNH2. 9 / 9
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"To investigate the possible mechanism underlying the hERG channel protein reduction induced by Ang II, we performed parallel experiment to compare the Western blots phenotypes of fluoxetine treatment,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ang II decreased hERG current in HEK293 cells and significantly delayed channel activation, deactivation and recovery from inactivation."
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"Correspondingly, we find that Ang II significantly enhances the time dependent reduction of mature hERG channel protein under the condition of inhibiting forward protein trafficking."
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"The data in Fig. 4 A illustrates the effects of lactacystin, a proteasome inhibitor, and bafilomycin A1, a lysosomal inhibitor, on hERG channel protein degradation induced by Ang II in HEK293 and hERG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the present study, RNF4 knockdown further decreased ATO- or Ang- II induced HERG channel degradation due to PML accumulation, independent of its E3 ligase activity."
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"Ang II significantly enhanced the time dependent reduction of mature hERG channel protein."
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"Ang II further significantly accelerated the degradation of the mature hERG protein."
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"In addition, the proteasomal inhibitor lactacystin (5muM) inhibited Ang II mediated the reduction of mature hERG channel protein, but the lysosomal inhibitor bafilomycin A1 (1muM) had no effect on the protein."
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"The data in Fig. 3 C summarized the time course of relative values of mature hERG channel protein and showed that Ang II significantly decreased the mature hERG channel protein compared to the control[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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