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Trans-aconitic acid inhibits JAK1. 1 / 1
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"Hydrophobic bile acids will inhibit Jak1- and Tyk2-phosphorylation, resulting in a decreased mRNA and protein expression of IFN-stimulated genes such as myxovirus resistance protein A (MxA) or dsRNA-activated protein kinase (PKR) thereby explaining interferon-ɑ resistance [ xref ]."