IndraLab

Statements

SPP1 binds ITGAV. 7 / 7
1 1 | 5
reach
"For ovine trophectoderm cells, SPP1 binds ITGAV : ITGB3 and perhaps ITGA5 : ITGB1 to induce focal adhesion assembly, a prerequisite for adhesion and migration through activation of : 1) ribosomal protein S6 kinase (RPS6K) via crosstalk between MTOR and MAPK pathways; 2) MTOR, phosphatidyl inositol kinase 3 (PIK3), MAPK3/MAPK1 (ERK1/2) and MAPK14 (P38) signaling to stimulate trophectoderm cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of trophectoderm cells."
22958877
hprd
No evidence text available
10835423
reach
"XREF_BIBR SPP1 binds ITGAV : ITGB3 and possibly ITGA5 : ITGB1integrin heterodimers to induce focal adhesion assembly, a prerequisite for adhesion and migration of oTr cells, through activation of (1) p70S6K via crosstalk between mTOR and MAPK pathways; (2) mTOR, PI3K, MAPK3/MAPK1 (ERK1/2), and MAPK14 (P38) signaling to stimulate oTr cell migration; and (3) focal adhesion assembly and myosin II motor activity to induce migration of oTr cells."
23050969
reach
"FN1 and SPP1 bind to ITGAV through a RGD containing domain, so their interaction can be blocked by a synthetic peptide GRGDS [XREF_BIBR, XREF_BIBR]."
27329720
biogrid
No evidence text available
7592829
reach
"ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion."
28250242
reach
"It has been shown that ITGB3 and ITGAV subunits together bind to SPP1 to generate stable adhesions between the maternal-fetal interface in pigs after the initial attachment of conceptus trophoblast to the endometrial luminal epithelium XREF_BIBR, XREF_BIBR."
24505325