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SPP1 binds ITGAV. 12 / 14
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"In co‐IP experiments, binding of SPP1 to ITGAV and ITGB5 was confirmed in ITGB1‐silenced HCC cells following CAF‐CM treatment; SPP1 also bound to ITGB1, ITGB5, and ITGAV in ITGB5‐silenced HCC cells; in HCC cells deficient for both ITGB1 and ITGB5, binding of SPP1 to integrins was not detected (Figure 5D)."
36919193
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"It is indicated that the association between ITGAV, SPP1, COL4A2, COMP, and immune cells may be involved in the progression of liver cancer.In addition, ROC analysis showed that ITGAV, SPP1, COL4A2, and COMP had a potential diagnostic value for liver cancer patients."
38374893
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"For ovine trophectoderm cells, SPP1 binds ITGAV : ITGB3 and perhaps ITGA5 : ITGB1 to induce focal adhesion assembly, a prerequisite for adhesion and migration through activation of : 1) ribosomal protein S6 kinase (RPS6K) via crosstalk between MTOR and MAPK pathways; 2) MTOR, phosphatidyl inositol kinase 3 (PIK3), MAPK3/MAPK1 (ERK1/2) and MAPK14 (P38) signaling to stimulate trophectoderm cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of trophectoderm cells."
22958877
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"FN1 and SPP1 bind to ITGAV through a RGD containing domain, so their interaction can be blocked by a synthetic peptide GRGDS [XREF_BIBR, XREF_BIBR]."
27329720
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"Meanwhile, in a fibrotic microenvironment, the binding of SPP1 to ITGAV inhibits the apoptosis of lung cancer cells [64]."
37874419
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"Key ligand-receptor interactions identified include MIF binding with CD74 + CXCR4 or CD74 + CD44, and SPP1 binding with CD44 or ITGAV + ITGB1 (Fig. 3B)."
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"ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion."
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"It has been shown that ITGB3 and ITGAV subunits together bind to SPP1 to generate stable adhesions between the maternal-fetal interface in pigs after the initial attachment of conceptus trophoblast to the endometrial luminal epithelium XREF_BIBR, XREF_BIBR."
24505325
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"XREF_BIBR SPP1 binds ITGAV : ITGB3 and possibly ITGA5 : ITGB1integrin heterodimers to induce focal adhesion assembly, a prerequisite for adhesion and migration of oTr cells, through activation of (1) p70S6K via crosstalk between mTOR and MAPK pathways; (2) mTOR, PI3K, MAPK3/MAPK1 (ERK1/2), and MAPK14 (P38) signaling to stimulate oTr cell migration; and (3) focal adhesion assembly and myosin II motor activity to induce migration of oTr cells."
23050969
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"A previous study showed that the binding of SPP1 and ITGAV during mammalian implantation triggers an adhesion cascade for the peri-implantation of luminal epithelial cells and the trophectoderm ( Fran[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36464341
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"Further, in females there was an increase in the expression of integrin and adhesion-associated genes, like Itga5 (associates with Itgb1) which binds fibronectin, Itgav (associates with Itgb3 and Itgb5) which binds vitronectin, osteopontin and bone sialoprotein (KEGG pathway: map04512), and ADAM8."
37485233
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"Additionally, in-depth single-cell RNA-sequencing analysis identified associations between SPP1 and ITGAV, ITGB1, CD44, MMP3, and FN1."
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