IndraLab

Statements

LEF1 inhibits CYLD. 4 / 4
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"TNFa induced necrotic signaling can be blocked in some chronic leukemias by the action of LEF1 (Lymphoid Enhancer binding Factor 1), which acts on the Wnt and betaCatenin pathway to downregulate CYLD at the transcriptional level [XREF_BIBR]."
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"CYLD was negatively regulated by LEF1, and this repression was abolished upon selenite treatment."
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"Our team has previously demonstrated that LEF1 is a transcriptional repressor of CYLD in CLL."
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"For example, RIP3 and CYLD are downregulated in chronic lymphocytic leukemia (CLL) because lymphoid enhancer-binding factor 1 (LEF1), which is a transcriptional repressor of CYLD, is upregulated [65]."
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