IndraLab

Statements


USP25 activates ERK. 4 / 4
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"Unlike USP33, which has been reported to inhibit mitogen activated protein kinase (MAPK) activation pathway and suppress hepatoma cell growth 26, our study suggests that USP21 activates ERK1/2 to promote HCC cell proliferation."

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"Unlike USP33, which has been reported to inhibit mitogen-activated protein kinase (MAPK) activation pathway and suppress hepatoma cell growth xref , our study suggests that USP21 activates ERK1/2 to promote HCC cell proliferation."

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"Moreover, USP21 could promote the malignant transformation of the normal human hepatocytes and increased the tumorigenicity of the HCC cells by activating the ERK signaling through the stabilization of MEK2."

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"USP21 activates ERK1/2 signaling through MEK2."