IndraLab

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USP25 activates ERK. 6 / 6
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"Unlike USP33, which has been reported to inhibit mitogen-activated protein kinase (MAPK) activation pathway and suppress hepatoma cell growth xref , our study suggests that USP21 activates ERK1/2 to promote HCC cell proliferation."
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"Unlike USP33, which has been reported to inhibit mitogen activated protein kinase (MAPK) activation pathway and suppress hepatoma cell growth 26, our study suggests that USP21 activates ERK1/2 to promote HCC cell proliferation."
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"USP21 deubiquitinated and stabilized MEK2, thus activating the ERK pathway for cell proliferation, colony formation, and cell cycle progression, and promoted tumor growth [54]."
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"Mechanistically, USP25 in macrophages promoted the activation of the ERK signaling pathway through deubiquitination and stabilization of B-Raf and C-Raf."
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"USP21 activates ERK1/2 signaling through MEK2."
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"Moreover, USP21 could promote the malignant transformation of the normal human hepatocytes and increased the tumorigenicity of the HCC cells by activating the ERK signaling through the stabilization of MEK2."
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