IndraLab

Statements

Chloride inhibits KCNH2. 5 / 5
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reach
"For example, decamethonium dibromide and benzyltrimethylammonium chloride did not inhibit the hERG channel, presumably because the charged nitrogen (s) in these compounds are exposed."
21362439
sparser
"In the present study, the potential mechanisms for HERG channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride, two most potent HERG channel inhibitors found among the QACs examined ( xref ), were studied using whole-cell patch clamp experiments in a CHO cell line stably expressing HERG channels."
23313619
sparser
"The study of mechanism of HERG channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride can provide additional insight of structure-activity relationship of HERG channel inhibition and the molecular determinants of the interaction between the compounds and HERG channel proteins."
23313619
sparser
"We found some similarities as well as differences in the electrophysiological properties of HERG channel inhibitions by tetra-n-octylammonium bromide and benzethonium chloride ( xref )."
23313619
sparser
"The properties of HERG channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride are highly similar to verapamil and cisapride ( xref )."
23313619