IndraLab

Statements


MTOR phosphorylates IRS1 on S639. 7 / 7
1 | 4 2

reach
"MTOR induced the serine phosphorylation of IRS-1 (Ser 636/639), and such phosphorylation was inhibited by rapamycin."

rlimsp
"Hepatocytes cultured with palmitate displayed hyperphosphorylation of IRS-1 at Ser residues 632/635, known to be phosphorylated by mTOR."

rlimsp
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR."

"Mtor induced the serine phosphorylation of irs-1 (ser-636/639), and such phosphorylation was inhibited by rapamycin. These results suggest that tnf impairs insulin signaling through irs-1 by activation of a pi 3-kinase/akt/mtor pathway, which is antagonized by pten"

reach
"At the molecular level, Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of IRS-1 and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."

reach
"Therefore, mTOR phosphorylates IRS-1 Ser 636/639 to control increasing concentrations of glucose in an insulin independent manner and suppresses IRS-1 associated PI3K and Akt signaling."

reach
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."