IndraLab

Statements


MTOR phosphorylates IRS1 on S639. 5 / 9
1 1 | 5 2

reach
"Therefore, mTOR phosphorylates IRS-1 Ser 636/639 to control increasing concentrations of glucose in an insulin independent manner and suppresses IRS-1 associated PI3K and Akt signaling."

reach
"MTOR induced the serine phosphorylation of IRS-1 (Ser 636/639), and such phosphorylation was inhibited by rapamycin."

reach
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."

reach
"At the molecular level, Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of IRS-1 and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."

reach
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."