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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP10 deubiquitinates AICDA. 5 / 5

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"USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID."

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"l USP10 overexpression decreased AID ubiquitination."

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"k USP10 knockdown promoted AID ubiquitination."

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"As shown in Fig. 1e, k, knockdown of USP10 disrupted AID stability and increased AID ubiquitination."

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"Alternatively, the overexpression of USP10, but not its catalytically inactive CA mutant (C424A), stabilized AID and decreased the ubiquitination of AID (Fig. 1f, l) ."

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USP10 deubiquitinates AICDA. 5 / 5

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