IndraLab

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USP10 deubiquitinates AICDA. 5 / 5
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"USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID."
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"l USP10 overexpression decreased AID ubiquitination."
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"k USP10 knockdown promoted AID ubiquitination."
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"As shown in Fig. 1e, k, knockdown of USP10 disrupted AID stability and increased AID ubiquitination."
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"Alternatively, the overexpression of USP10, but not its catalytically inactive CA mutant (C424A), stabilized AID and decreased the ubiquitination of AID (Fig. 1f, l) ."
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