IndraLab

Statements

USP7 binds USP9X. 9 / 9
2 | 1 6
sparser
"FAM188B binds to USP7 and destabilizes the USP7-p53 interaction, thereby promoting p53 ubiquitination and degradation ( xref (iv))."
35008383
sparser
"By systematically analyzing, Yu Zhao et al. demonstrated that the OTUD4 could complex with USP7-USP9X. They proved that the OTUD4-USP7-USP9X complex was required for alkylation damage resistance and repair via promoting stability of ALKBH3, a demethylases for alkylation damage repair [ xref ]."
31011293
biogrid
No evidence text available
35926709
biogrid
No evidence text available
30224337
sparser
"To achieve this, the 181–550 region of OTUD4, which does not include the OTU catalytic domain, forms a complex with USP7 and USP9X. These two enzymes remove the K48-linked ubiquitin chains of ALKBH2 and ALKBH3 by their DUB activity, thereby preventing their degradation by the proteasome ( xref )."
38455765
sparser
"In our study, however, the amount of FAM188B-bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."
29795372
sparser
"The specificity of the USP9X and USP7 interaction was examined using unrelated DUBs, including USP4 ( xref ) and USP8 (data not shown), neither of which affected MARCH7 levels."
18410486
sparser
"Conversely, USP7 interacts with FAM188B and enhances tumor growth and survival of colon cancer cells[ xref , xref ]."
38292842
reach
"Additionally, we conducted Co-IP experiments in NRK-52E cells to verify the binding situation, and the results demonstrated varying degrees of binding between Usp49, Stambp, Usp8, Usp9x, Usp33, Usp20, and Usp7 with TLR4."
38874156