IndraLab

Statements

USP25 inhibits GLI1. 4 / 4
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"On the other hand, USP21 overexpression similarly represses Gli1 transcriptional activity, which is at odds with increased Gli1 protein levels."
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"USP21 is able to interact with GLI1, thereby suppressing GLI1 dependent transcription."
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"Likewise, overexpression of GFP-USP21 inhibited Gli1 transcriptional activity to a similar degree, and this inhibition depended on its catalytic activity (XREF_FIG C)."
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"In this assay, siRNA mediated depletion of USP21 decreased Gli1 transcriptional activity by ~ 40% (XREF_FIG B)."
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