IndraLab

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COPS6 increases the amount of FASN. 3 / 3
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"Further, CSN6 KD tumors demonstrate decreased FASN protein levels based on immunohistochemistry (IHC) staining (Fig. 6i) and immunoblotting (Supplementary Fig. 4h), low BODIPY staining (Fig. 6j) and relatively low levels of tumor cell growth (as measured by Ki67 staining) (Fig. 6i), while CSN6-reexpressing tumors can restore the levels of FASN (Fig. 6i, Supplementary Fig. 4h), increase BODIPY staining (Fig. 6j), and elevate Ki67 staining concurrently (Fig. 6i)."
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"We previously have shown that CSN6 is a positive regulator of c-Myc, it remains to been seen whether CSN6 can enhance FASN gene expression through c-Myc although we have observed that CSN6 have no impact on FASN mRNA expression."
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"Indeed, CSN6 overexpression increased the protein level of FASN, but not affected the mRNA expression level of FASN in several CRC cell lines (Fig. 2f)."
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