IndraLab

Statements

Curcumin inhibits IRF3. 3 / 3
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"Curcumin inhibited DeltaTLR4 induced NF-kappaB and IRF3 activation."
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"However, curcumin did not inhibit interferon regulatory factor 3 (IRF3) activation induced by another immediate TLR4 downstream component TIR-domain-containing adaptor inducing interferon-beta (TRIF), suggesting that the target of curcumin is the receptor itself, but not the downstream components of TRIF pathway [XREF_BIBR]."
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"However, in TRIF dependent pathway, curcumin did not inhibit IRF3 activation induced by overexpression of TRIF in 293T cells."
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