IndraLab

Statements

Modified USP8 leads to the deubiquitination of SMO. 4 / 4
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reach
"Consistent with UBPY being able to counteract Smo ubiquitination independent of Hh signaling states, overexpression of UBPY reduced Smo ubiquitination in S2 cells both in the absence and presence of Hh (XREF_FIG)."
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"Moreover, overexpression of USP8 prevents Smo ubiquitination and elevates Smo accumulation, leading to increased Hh signaling activity."
22253573
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"Overexpression of Flag-USP8 in S2 cells reduced Smo ubiquitination (XREF_FIG, lane 3, top panel), whereas knockdown of USP8 by RNAi enhanced the levels of ubiquitinated Smo (XREF_FIG, lane 2, top panel), which was consistent with the data from the screen."
22253573
reach
"The overexpression of USP8 down-regulated Smo ubiquitination and increased Smo accumulation."
22253573