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USP8 activates PI3K. 4 / 4
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"This current study showed that the EGFR, PI3K, and NF-κB signaling is downregulated and upregulated in PCa by USP8 silencing and overexpressing, respectively ( Figure 4 )."
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"As USP8 silencing significantly inhibited the PCa cell growth, proliferation, and metastasis and induced apoptosis and suppressed NF-kB signal activation by decreasing EGFR and PI3K, the USP8-specific inhibitor might be a novel therapeutic target to suppress PCa cell growth, proliferation, and metastasis."
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"In contrast, the USP8-specific siRNA reduced EGFR and PI3K, suppressing the NF-kB signal."
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"Thereby , together with these data , it can be concluded that the elevated level of USP8 not only increases the expression of EGFR , PI3K , and P-Akt but also might increase the PI3K and P-Akt expression over EGFR silencing where the PI3K and P-Akt well established the downstream target of EGFR ( Figures 6C , D ) ."
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