IndraLab

Statements

Modified AKT decreases the amount of MYC. 3 / 3
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"Akt overexpression significantly abolished saurolactam induced decrease in protein and phosphorylation levels of Akt, c-Myc, and Skp2 protein levels, implying that Akt inactivation was a causal mediator of saurolactam induced inhibition of c-Myc and Skp2."
25627547
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"Overexpression of AKT considerably reversed the taxifolin induced decrease in AKT, c-myc and SKP-2 protein expression and the decrease in AKT phosphorylation, suggesting that inactivation of AKT was a mediator of taxifolin induced inhibition of c-myc and SKP-2."
29257319
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"In our hands, activated PI-3-K reduced the stability of c-Myc, because (i) the PI-3-K inhibitor, LY294002, prevented the reduction in c-Myc levels induced by MPEP; and (ii) over-expression of AKT promoted c-Myc ubiquitination."
16987252