IndraLab

Statements

SDC4 binds SPP1. 15 / 18
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"Therefore, we asked whether the binding of syndecan-4 to OPN is dependent on HS or CS chains."
18158320
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"Therefore, it is of importance to examine whether syndecan-4 can associate with OPN and modulate OPN function."
18158320
sparser
"Therefore, we asked whether the binding of syndecan-4 to OPN is dependent on HS or CS chains."
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"We further tested whether the interaction of OPN and syndecan-4 occurs under physiological conditions."
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"OPN and syndecan-4 proteins were immunoblotted in the bound fraction from the anti-syndecan-4 antibody coupled column but not from the control column, indicating the presence of association between OPN and syndecan-4."
18158320
sparser
"Therefore, we examined whether syndecan-4 binds to OPN in vitro."
18158320
sparser
"Therefore, it is of importance to examine whether syndecan-4 can associate with OPN and modulate OPN function."
18158320
sparser
"It is known that OPN, αvβ3, and α4β1 (also known as very late antigen 4) integrins are involved in recruitment and cell adhesion of inflammatory cells ( xref , xref , xref , xref , xref , xref ), and it is likely that the association of syndecan-4 and OPN may result in the inhibition of integrin-mediated inflammation."
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sparser
"Therefore, the recognition of OPN by an RGD-recognizing integrin receptor such as αvβ3 can be blocked when OPN is bound by syndecan-4."
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sparser
"We further tested whether the interaction of OPN and syndecan-4 occurs under physiological conditions."
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sparser
"In addition, we confirmed the association of OPN and syndecan-4 by using genetically manipulated CHO cells transiently expressing human OPN, syndecan-4, or both OPN and syndecan-4 (Fig. S4, available at)."
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"Therefore, the recognition of OPN by an RGD recognizing integrin receptor such as alphavbeta3 can be blocked when OPN is bound by syndecan-4."
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"Therefore, we examined whether syndecan-4 binds to OPN in vitro."
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"Syndecan-4, when bound to OPN, masks not only thrombin cleavage but also integrin binding sites within OPN molecules, thus regulating various OPN functions."
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sparser
"We thus examined whether the association of OPN and syndecan-4 modulates the availability of OPN to thrombin and/or its receptors."
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