IndraLab

Statements

USP20 activates HMGCR. 6 / 6
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"This licenses USP20’s recruitment into the HMGCR complex and antagonizes its degradation, thereby stabilizing HMGCR and promoting cholesterol synthesis [133]."
36038892
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"Inhibition of USP20 can promote HMGCR degradation and decrease lipid synthesis."
35754818
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"Besides decreasing HMGCR and lipid biosynthesis, knock-out or silencing of Usp20 led to the increase of UCP1 and energy expenditure in BAT and iWAT (Figs."
39173829
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"Owing to the chronic activity of p-mTOR, more USP20-mediated stabilization of HMGCR was observed in the HFD group than in the control group upon re-feeding."
37916105
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"This observation suggests that alternative regulatory mechanisms may be involved in mediating TBBPA’s effects on hepatic lipid metabolism.Our findings reveal a previously unrecognized mechanism underlying TBBPA-induced dyslipidemia, centered on post-transcriptional regulation of cholesterol synthesis through USP20-mediated HMGCR stabilization."
39998957
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"By contrast, USP20 inhibition promotes HMGCR degradation, reduces lipid biosynthesis, enhances succinate production, and promotes heat generation."
36382190