IndraLab

Statements

Melatonin inhibits MAPK8. 4 / 5
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"Melatonin can inactivate JNK1, which further inhibits the separation of Bcl-2 from Beclin-1."
38375039
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"Melatonin supplementation in LPC-treated rats dose-dependently diminished GFAP, ED1, p-ERK, p-JNK, and p-p38 immunoreactivity as well as pro-inflammatory cytokine release and neuropathic pain behavior[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Melatonin also decreased ER stress markers (GRP78, ATF6, IRE1α, and PERK) and reduced pro-apoptosis markers (Bax, Bak, P-JNK, cleaved caspase 3 and 9) while increasing Bcl2 levels and melatonin receptor 2 (MT2) expression."
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"Melatonin with antioxidant property could also inhibit another important cell death signaling pathway enzyme c-Jun N-terminal kinase 1, which is usually stimulated by increased oxidative stress after exposure to potentially toxic substances [219,239]."
32998479