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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

REST decreases the amount of KCNQ3. 2 / 2

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reach

"We also show that expression of both KCNQ2 and KCNQ3 is repressed by the Repressor Element 1-Silencing Transcription factor (REST) and that expression of REST in neurons is sufficient to repress KCNQ2 and KCNQ3 expression, inhibiting functional expression of the M-current and resulting in hyperexcitable neurons."

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trrust

No evidence text available

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...