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USP14 deubiquitinates DDX58. 2 / 2

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"n this study, we demonstrated USP14, a deubiquitinating enzyme, as a negative regulator in antiviral responses by directly deubiquitinating K63-linked RIG-I."

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"Furthermore, USP14 is a negative regulator in antiviral responses because it directly deubiquitinates K63-linked ubiquitin on retinoic acid-inducible gene I (RIG-I), which is a critical RNA virus sensor that initiates the antiviral immune response (31)."

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USP14 deubiquitinates DDX58. 2 / 2

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