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USP14 deubiquitinates RIGI. 3 / 3
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"<span class="match term0">USP14</span> promotes K63-linked <span class="match term1">RIG-I</span> deubiquitination and suppresses antiviral immune responses"
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"However, USP14 promotes retinoic acid inducible gene 1 protein (RIG-I) deubiquitination at K63, which is important for inhibiting antiviral immune reaction."
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"Furthermore, USP14 is a negative regulator in antiviral responses because it directly deubiquitinates K63-linked ubiquitin on retinoic acid-inducible gene I (RIG-I), which is a critical RNA virus sensor that initiates the antiviral immune response (31)."
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