IndraLab

Statements

COPS6 binds COPS4. 36 / 36
21 4 | 1 10
biogrid
No evidence text available
31444342
sparser
"The key structural rearrangements include: (i) the presence of a neddylated SCF triggers the convergence of the N-terminal helical arms of CSN2 and CSN4 (hereafter CSN2 arm and CSN4 arm respectively), clamping CUL1 CTD and RBX1 RING , (ii) the flexible CUL1 WHB is repositioned against the stabilised RBX1 RING , aligning NEDD8 at the CSN active site and (iii) concurrent disruption of the CSN4-CSN6 interface enables flexibility and remodelling of the CSN5-CSN6 MPN domains, bringing the CSN5 active site closer to NEDD8 (Fig.  xref )."
41577659
biogrid
No evidence text available
32034103
biogrid
No evidence text available
19295130
biogrid
No evidence text available
22863883
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32034103
biogrid
No evidence text available
33961781
biogrid
No evidence text available
36652389
biogrid
No evidence text available
21145461
biogrid
No evidence text available
26344197
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19141280
sparser
"Upon CRL–CSN engagement, the CRLs dock between CSN2 and CSN4, weakening the CSN4–CSN6 interface and releasing the CSN5–CSN6 MPN dimer."
41095159
sparser
"In the absence of a bound neddylated CRL substrate, the CSN isopeptidase is inhibited by the CSN5 Ins-1 loop bearing Glu 104 and separately through the CSN4–CSN6 interface ( xref D) [ xref ]."
35883466
sparser
"A total of 18 cross-links were identified involving CSN4: 12 of which were intra-CSN4 cross-links, 4 between CSN2-CSN4 and 2 between CSN6–CSN4."
31444342
biogrid
No evidence text available
22939629
biogrid
No evidence text available
32296183
sparser
"Removal of the CSN6 Ins-2 loop has been shown in CSN–CRL1~N8 to disrupt the CSN4–CSN6 interface, leading to sustained enzymatic activity of the CSN xref ."
31444342
sparser
"In future studies, targeted deletion of the CSN6 Ins-2 loop can be performed alongside differential HDX-MS for the CSN–CRL2 system, to further probe the differences in active site remodelling of CSN5 as a result of disrupting the CSN4–CSN6 interface."
31444342
sparser
"Using yeast-two-hybrid assay, a strong interaction between mouse Csn4 and Csn6 was detected ( xref ), in agreement with previous published data (reviewed in xref , xref )."
22956996
biogrid
No evidence text available
35831314
sparser
"Similar experiment using individual truncation mutants of Csn6 demonstrate that Csn4 interacts with the C-terminal region of Csn6 that exclude most of the MPN − domain, but not with the amino terminal part of Csn6 ( xref , xref )."
22956996
biogrid
No evidence text available
23086934
biogrid
No evidence text available
23086934
sparser
"In addition to the Csn5-Csn6 interaction, nine other interaction pairs were detected in this study, including Csn1-Csn2, Csn1-Csn3, Csn1-Csn4, Csn2-Csn3, Csn3-Csn4, Csn3-Csn6, Csn4-Csn6, Csn4-Csn7, and Csn6-Csn7 ( xref )."
37168110
reach
"Using yeast-two-hybrid assay, a strong interaction between mouse Csn4 and Csn6 was detected (XREF_SUPPLEMENTARY), in agreement with previous published data."
22956996
biogrid
No evidence text available
23086934
biogrid
No evidence text available
19295130
sparser
"Several interactions, including Csn1-Csn2, Csn1-Csn4, Csn4-Csn7, Csn4-Csn6, and Csn5-Csn6, were all demonstrated in these organisms ( xref ; xref )."
37168110
biogrid
No evidence text available
27173435
hprd
No evidence text available
11337588
hprd
No evidence text available
14647295
hprd
No evidence text available
9707402
hprd
No evidence text available
11285227