IndraLab

Statements

BRCC3 activates NLRP6. 5 / 5
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"The potential mechanism by which BRCC3 activates the NLRP6 inflammasome has been preliminarily discussed."
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"BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome."
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"In MCAO mouse neurons and OGD/R neurons, BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) was highly expressed, which activated the NLRP6 inflammasome, leading to pyroptosis [49]."
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"19 BRCC3 activates the NLRP6 inflammasome in rats."
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"Therefore, investigating these aspects will provide deeper insights into the involvement of BRCC3 in neuroinflammation and pyroptosis, potentially paving the way for novel therapeutic strategies to mitigate the harmful effects of cerebral I/R injury and improve the neurological outcomes in patients.We aimed to explore the effect of BRCC3 in neuroinflammation and pyroptosis after cerebral I/R injury in mice and the potential mechanism via which BRCC3 activates the NLRP6 inflammasome.3 RESULTS."
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