IndraLab

Statements

RUNX1 binds USP48. 7 / 7
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"To verify whether the two proteins interact with each other, through co-IP, and the results show that RUNX1 can bind to USP31 (Fig.  xref D)."
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"As RUNX1 can bind to USP31, to further investigate the interaction by searching for inhibitors against both by Genomics of Drug Sensitibity in Cancer (GDSC)."
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"The docking results with the lowest binding energy are shown in Fig.  xref B. Therefore, we selected MP470 for interfering with the interaction between RUNX1 and USP31."
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"The results showed that MP470 increased the ubiquitination level of RUNX1, leading to a decrease in RUNX1 protein level, which may be due to its inhibition of the interaction between RUNX1 and USP31."
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"Taken together, these data further supported that the binding of USP31 to RUNX1, and showed that USP31 could mediate the deubiquitination of RUNX1 and regulate its transcriptional function."
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"In addition, there may be an interaction between the two proteins, RUNX1 and USP31, with modification of deubiquitination leading to upregulation of RUNX1 level expression (Fig.  xref )."
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"MP470 was chosen as an inhibitor of the interaction between USP31 and RUNX1, results suggested that the USP31 protein acts through deubiquitination to affect the RUNX1 protein."
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