IndraLab

Statements

OTULIN inhibits cell death. 10 / 10
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"The protease OTULIN, revealed by Dixit and colleagues to limit cell death and inflammation via ubiquitin (regulatory protein) modification (22), is another potential therapeutic target."
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"Third, we show that OTULIN phosphorylation is counteracted by the dual-specificity phosphatase DUSP14, which we identify as an OTULIN phosphatase that limits cell death."
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"Collectively, these data indicate that OTULIN limits both apoptosis and necroptosis.To address the mechanisms by which OTULIN inhibited cell death, we first sought to verify whether LUBAC activity was[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mutation of Tyr56 in the OTULIN PIM domain abrogates HOIP binding, resulting in reduced ability of OTULIN to inhibit NF-kappaB activity and reduced cell death signaling [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Genetic loss of Otulin in mice or expression of a knock-in C129A variant leads to embryonic lethality at E10.5 (30, 35), with the C129A-expression mice showing extensive cell death in the yolk sac and placenta (35)."
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"However, both overexpression and knockdown of OTULIN sensitized cells to TNFalpha induced cell death, suggesting more complex roles for Met1 linkages in balancing signaling pathways downstream of the TNFalpha receptor."
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"This suggests that loss of OTULIN does not cause aberrant cell death in immune cells (XREF_FIG E) and that the high levels of cytokines and chemokines present activate the entire immune cell population."
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"These data are consistent with OTULIN preventing autoinflammation by suppressing aberrant cell death, with intriguing differences observed in the TNF-dependence of these death programs in different cell types."
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"OTULIN limits cell death and inflammation by deubiquitinating LUBAC."
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"Furthermore , Otulin inactivation reduces TNFR1 complex formation and increases cell death [ 83 ] ."
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