IndraLab

Statements

OTULIN inhibits cell death. 5 / 5
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eidos
"Furthermore , Otulin inactivation reduces TNFR1 complex formation and increases cell death [ 83 ] ."
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"However, both overexpression and knockdown of OTULIN sensitized cells to TNFalpha induced cell death, suggesting more complex roles for Met1 linkages in balancing signaling pathways downstream of the TNFalpha receptor."
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"OTULIN limits cell death and inflammation by deubiquitinating LUBAC."
29950720
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"This suggests that loss of OTULIN does not cause aberrant cell death in immune cells (XREF_FIG E) and that the high levels of cytokines and chemokines present activate the entire immune cell population."
27523608
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"Mutation of Tyr56 in the OTULIN PIM domain abrogates HOIP binding, resulting in reduced ability of OTULIN to inhibit NF-kappaB activity and reduced cell death signaling [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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