IndraLab
Statements
Lipopolysaccharide increases the amount of CACNA1C. 2 / 2
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2
reach
"Moreover, we showed that LPS increased MAMs formation and intracellular Ca 2+ levels, enhanced the expression of Cav1.2 and RyR2, decreased mitochondrial membrane potential and intracellular ATP levels, and promoted mitochondrial fragmentation, the expression of mitophagy proteins and ROS production in H9c2 cells, which were reversed by knockdown of FUNDC1 and IL-6/STAT3 inhibitor including Bazedoxifene and Stattic."
reach
"Co-culture with LPS stimulated macrophage medium inhibited CACNA1C expression in atrial myocytes, which was restored by IL-1beta knockout in macrophages using the CRISPR and Cas9 system, suggesting that repression of CACNA1C expression by LPS stimulated macrophage medium was mediated by IL-1beta."