IndraLab

Statements


COPS5 activates Cyclin. 2 / 2
| 2

reach
"Transfection of wild-type mouse CSN5 cDNA, which differs by two nucleotides from human CSN5 in the region that is targeted by the silencing shRNA, restored wild-type levels of both Skp2 and cyclin F."

reach
"Ectopic expression of Jab1 and CSN5 induces specific down-regulation of the cyclin dependent kinase (Cdk) inhibitor p27 (p27 (Kip1)) in a manner dependent upon transportation from the nucleus to the cytoplasm."