IndraLab

Statements

MDM2 binds USP15. 7 / 9
1 | 3 3
sparser
"USP15 physically interacts with MDM2 and inhibits the ubiquitination and degradation of MDM2."
30054854
reach
"First, USP15 interacts with MDM2, inhibits ubiquitination, and stabilizes MDM2, an important E3 ligase that mediates the ubiquitination and proteolysis of NFATc2 members of the NFAT family and negatively regulates TCR signals."
32850399
sparser
"When co-expressed in HEK293 cells, USP15 interacted with MDM2, as detected by co-IP assays ( xref )."
24777531
sparser
"First, USP15 interacts with MDM2, inhibits ubiquitination, and stabilizes MDM2, an important E3 ligase that mediates the ubiquitination and proteolysis of NFATc2 members of the NFAT family and negatively regulates TCR signals."
32850399
reach
"When co-expressed in HEK293 cells, USP15 interacted with MDM2, as detected by co-IP assays (XREF_FIG)."
24777531
reach
"These results suggest that USP15 physically interacts with MDM2 in a p53 independent manner."
24777531
biogrid
No evidence text available
27893708